From the cell cytoskeleton to connective tissues, fibrous networks are ubiquitous in
metazoan life as the key promoters of mechanical strength, support and integrity. In recent …

This review highlights recent research on Achilles tendon healing, and comments on the
current clinical controversy surrounding the diagnosis and treatment of injury. The processes …

This review highlights recent research on structure–function relationships in tendon and
comments on the parallels between development and healing. The processes of tendon …

Abstract In his Lissner Award medal lecture in 2000, Stephen Cowin asked the
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …

BACKGROUND: Collagen fiber re-alignment and uncrimping are two postulated
mechanisms of tendon structural response to load. Recent studies have examined structural …

Purpose To develop a clinically relevant, robust murine model of rotator cuff tendon repair to
examine cellular and molecular mechanisms of healing. Methods Sixty C57BL/6 male mice …

Tendons function to transfer load from muscle to bone through their complex composition
and hierarchical structure, consisting mainly of type I collagen. Recent evidence suggests …

Mechanical deformation applied at the joint or tissue level is transmitted through the
macroscale extracellular matrix to the microscale local matrix, where it is transduced to cells …

Background: Over the past several decades, there has been a steady increase in pediatric
anterior cruciate ligament (ACL) tears, particularly in young female basketball and soccer …

As tendons are loaded, they reduce in volume and exude fluid to the surrounding medium.
Experimental studies have shown that tendon stretching results in a Poisson's ratio greater …