Since the first high-resolution structure of the nucleosome was reported in 1997, the
available information on chromatin structure has increased very rapidly. Here, we review …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and
polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their …

Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that
regulate genomic architecture. Here, we present a structural model of the endogenously …

Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …

Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …

Unlike other chromatin remodelers, INO80 preferentially mobilizes hexasomes, which can
form during transcription. Why INO80 prefers hexasomes over nucleosomes remains …

The chromatin-remodelling complex SWI/SNF is highly conserved and has critical roles in
various cellular processes, including transcription and DNA-damage repair,. It hydrolyses …

Transcription factors (TFs) interact with several other proteins in the process of
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …