The kidney has a remarkable ability of repair after acute kidney injury (AKI). However, when
injury is severe or persistent, the repair is incomplete or maladaptive and may lead to …

Acute kidney injury (AKI) is an increasing health burden with high morbidity and mortality
rates worldwide. AKI is a risk factor for chronic kidney disease (CKD) development and …

Psoriasis is a representative inflammatory skin disease occupied by large surface
involvement. As inflammatory cells and cytokines can systemically circulate in various …

Renal inflammation is the initial, healthy response to renal injury. However, prolonged
inflammation promotes the fibrosis process, which leads to chronic pathology and eventually …

Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and
hyperreactivity of the immune response at various levels, including hyperactivation of …

The nuclear factor of activated T cells (NFAT5), also known as a tonicity-responsive
enhancer-binding protein, was originally identified as a key transcription factor involved in …

Background The adverse effect of excessive salt intake has been recognized in decades.
Researchers have mainly focused on the association between salt intake and hypertension …

Acute kidney injury (AKI) and progressive chronic kidney disease (CKD) are intrinsically tied
syndromes. In this regard, the acutely injured kidney often does not achieve its full …

Besides assisting the maintenance of blood pressure and sodium homeostasis, the renin-
angiotensin system (RAS) plays a pivotal role in pathogenesis of acute kidney injury (AKI) …

It is well established that biglycan, a small leucine‐rich proteoglycan, acts as an extracellular
matrix‐derived danger signal in its soluble form. By binding to innate immunity Toll‐like …