Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key roles in excitatory synaptic …

Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

Myelination is essential for rapid impulse conduction in the CNS, but what determines
whether an individual axon becomes myelinated remains unknown. Here we show, using a …

l-3, 4-Dihydroxyphenylalanine (l-DOPA) remains the most effective symptomatic treatment of
Parkinson's disease (PD). However, long-term administration of l-DOPA is marred by the …

Glutamate-mediated damage to oligodendrocytes contributes to mental or physical
impairment in periventricular leukomalacia (pre-or perinatal white matter injury leading to …

Memantine is a clinically useful drug in many neurological disorders, including Alzheimer's
disease. The principal mechanism of action of memantine is believed to be the blockade of …

Glial cells of the nervous system directly influence neuronal and synaptic activities by
releasing transmitters. However, the physiological consequences of this glial transmitter …

GluN3-containing NMDA receptors (GluN3-NMDARs) are rarer than the'classical'NMDARs,
which are composed solely of GluN1 and GluN2 subunits, and have non-conventional …