Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

C Lüscher, PA Slesinger - Nature Reviews Neuroscience, 2010 - nature.com
G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in
response to activation of many different G protein-coupled receptors and thus control the …

[PDF][PDF] K+ Channels: Function‐Structural Overview

C González, D Baez‐Nieto, I Valencia… - Comprehensive …, 2012 - academia.edu
Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Supramolecular assemblies and localized regulation of voltage-gated ion channels

S Dai, DD Hall, JW Hell - Physiological reviews, 2009 - journals.physiology.org
This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases …

G‐protein mediated gating of inward‐rectifier K+ channels

MD Mark, S Herlitze - European Journal of Biochemistry, 2000 - Wiley Online Library
G‐protein regulated inward‐rectifier potassium channels (GIRK) are part of a superfamily of
inward‐rectifier K+ channels which includes seven family members. To date four GIRK …

Neuronal G protein-gated K+ channels

H Luo… - American Journal of …, 2022 - journals.physiology.org
G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

Characterization of a hyperpolarization‐activated time‐dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium

JR Ehrlich, TJ Cha, L Zhang, D Chartier… - The Journal of …, 2004 - Wiley Online Library
Cardiomyocytes from the pulmonary vein sleeves (PVs) are known to play an important role
in atrial fibrillation. PVs have been shown to exhibit time‐dependent hyperpolarization …

Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0

PR Stanfield, S Nakajima, Y Nakajima - Reviews of physiology …, 2007 - Springer
There are seven sub-families of Kir channels (Table 1), many of which have several
members. The sub-families are denoted Kit1. 0 to Kit7. 0 in the nomenclature introduced by …

Kir channel molecular physiology, pharmacology, and therapeutic implications

M Cui, L Cantwell, A Zorn, DE Logothetis - Pharmacology of Potassium …, 2021 - Springer
For the past two decades several scholarly reviews have appeared on the inwardly rectifying
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …

The roles of Gβγ and Gα in gating and regulation of GIRK channels

N Dascal, U Kahanovitch - International review of neurobiology, 2015 - Elsevier
Abstract G protein-gated K+(GIRK, or Kir3) channels mediate inhibitory neurotransmission
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …

Cyclic AMP–dependent protein kinase phosphorylation facilitates GABAB receptor–effector coupling

A Couve, P Thomas, AR Calver, WD Hirst… - Nature …, 2002 - nature.com
GABA (γ-aminobutyric acid) B receptors are heterodimeric G protein–coupled receptors that
mediate slow synaptic inhibition in the central nervous system. Here we show that the …