Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second
messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9 …

Prompted by the ground-breaking discovery of the rodent odorant receptor (OR) gene family
within the olfactory epithelium nearly 30 years ago, followed by that of OR genes in cells of …

Study of monogenic forms of obesity has demonstrated the pivotal role of the central leptin–
melanocortin pathway in controlling energy balance, appetite and body weight. The majority …

We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with
markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The …

Scope Eugenol (EU), the major aromatic compound derived from clove oil, is being focused
recently due to its potential in preventing several chronic conditions. Herein, this study aims …

Objective Obesity is a major risk factor for multiple diseases and is in part heritable, yet the
majority of causative genetic variants that drive excessive adiposity remain unknown. Here …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in
men, and the sixth in women. Non-alcoholic fatty liver disease (NAFLD) is now one of the …

Folic acid (FA) supplementation may protect from obesity and insulin resistance, the effects
and mechanism of FA on chronic high-fat-diet-induced obesity-related metabolic disorders …

Animal domestication is a process of environmental modulation and artificial selection
leading to permanent phenotypic modifications. Recent studies showed that phenotypic …

Ectopic expression and functions of odorant receptors (ORs) in the human body have
aroused much interest in the past decade. Mouse olfactory receptor 23 (MOR23, olfr16) and …