Aneuploidy as a promoter and suppressor of malignant growth
Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …
but the connection between chromosomal errors and malignant growth has remained …
[HTML][HTML] The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
Human pluripotent stem cells (PSCs) are a leading candidate for cell-based therapies
because of their capacity for unlimited self renewal and pluripotent differentiation. These …
because of their capacity for unlimited self renewal and pluripotent differentiation. These …
Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics
Human pluripotent stem cells (hPSCs) provide powerful resources for application in
regenerative medicine and pharmaceutical development. In the past decade, various …
regenerative medicine and pharmaceutical development. In the past decade, various …
Induced pluripotency: history, mechanisms, and applications
M Stadtfeld, K Hochedlinger - Genes & development, 2010 - genesdev.cshlp.org
The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …
ISSCR standards for the use of human stem cells in basic research
The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro
surrogate of a biological system. For the results and outputs from this research to be …
surrogate of a biological system. For the results and outputs from this research to be …
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
The utility of induced pluripotent stem (iPS) cells for investigating the molecular logic of
pluripotency and for eventual clinical application is limited by the low efficiency of current …
pluripotency and for eventual clinical application is limited by the low efficiency of current …
Genetic and epigenetic variations in iPSCs: potential causes and implications for application
The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has
revolutionized the field of regenerative medicine. However, recent studies on the genetic …
revolutionized the field of regenerative medicine. However, recent studies on the genetic …
[HTML][HTML] Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
Genomic stability is critical for the clinical use of human embryonic and induced pluripotent
stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on …
stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on …
A scalable system for production of functional pancreatic progenitors from human embryonic stem cells
TC Schulz, HY Young, AD Agulnick, MJ Babin… - PloS one, 2012 - journals.plos.org
Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will
require the translation of proof-of-principle concepts into a scalable, controlled, and …
require the translation of proof-of-principle concepts into a scalable, controlled, and …