[HTML][HTML] Nanomaterials designed for antiviral drug delivery transport across biological barriers

FD Cojocaru, D Botezat, I Gardikiotis, CM Uritu, G Dodi… - Pharmaceutics, 2020 - mdpi.com
Viral infections are a major global health problem, representing a significant cause of
mortality with an unfavorable continuously amplified socio-economic impact. The increased …

Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: Formulation–Processing aspects and challenges

A Bhakay, M Rahman, RN Dave, E Bilgili - Pharmaceutics, 2018 - mdpi.com
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …

Engineered nanocrystal technology: in-vivo fate, targeting and applications in drug delivery

VK Pawar, Y Singh, JG Meher, S Gupta… - Journal of Controlled …, 2014 - Elsevier
Abstract Formulation of nanocrystals is a robust approach which can improve delivery of
poorly water soluble drugs, a challenge pharmaceutical industry has been facing since long …

[HTML][HTML] Best practices in current models mimicking drug permeability in the gastrointestinal tract-An UNGAP review

JP O'Shea, P Augustijns, M Brandl, DJ Brayden… - European Journal of …, 2022 - Elsevier
The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at permeability assessment methods and pharmacokinetic properties …

D Babadi, S Dadashzadeh, M Osouli… - Journal of controlled …, 2020 - Elsevier
The therapeutic efficacy of orally administered drugs is often restricted by their inherent
limited oral bioavailability. Low water solubility, limited permeability through the intestinal …

Enhanced Oral Bioavailability of Efavirenz by Solid Lipid Nanoparticles: In Vitro Drug Release and Pharmacokinetics Studies

PK Gaur, S Mishra, M Bajpai… - BioMed research …, 2014 - Wiley Online Library
Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance
the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from …

Design space and QbD approach for production of drug nanocrystals by wet media milling techniques

L Peltonen - Pharmaceutics, 2018 - mdpi.com
Drug nanocrystals are nanosized solid drug particles, the most important application of
which is the improvement of solubility properties of poorly soluble drug materials. Drug …

Optimization of formulation and process parameters for the production of carvedilol nanosuspension by wet media milling

D Medarević, J Djuriš, S Ibrić, M Mitrić… - International journal of …, 2018 - Elsevier
The aim of this study is to develop nanosuspension of carvedilol (CRV) by wet media milling.
Concentration of polymeric stabilizer (hydroxypropyl cellulose-HPC-SL), milling speed and …

How to improve solubility and dissolution of irbesartan by fabricating ternary solid dispersions: optimization and in-vitro characterization

A Akram, M Irfan, WA Abualsunun, DM Bukhary… - Pharmaceutics, 2022 - mdpi.com
The purpose of this study is to improve the solubility and dissolution of a poorly soluble drug,
Irbesartan, using solid dispersion techniques. For that purpose, different polymers such as …

A quality by design (QbD) approach in pharmaceutical development of lipid-based nanosystems: A systematic review

DM Zagalo, BMA Silva, C Silva, S Simoes… - Journal of Drug Delivery …, 2022 - Elsevier
Over the last few decades, there has been an impressive progress on developing novel drug
delivery systems and targeted therapies through the use of Nanotechnology. In particular …