The efficient spread of malaria from infected humans to mosquitoes is a major challenge for
malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to …

Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

Malaria elimination means cessation of parasite transmission. At present, the declining
malaria incidence in many countries has made elimination a feasible goal. Transmission …

Control measures have significantly reduced malaria morbidity and mortality in the last two
decades; however, the downward trends have stalled and have become complicated by the …

Degeneracy in the genetic code allows multiple codon sequences to encode the same
protein. Codon usage bias in genes is the term given to the preferred use of particular …

Existing control measures have significantly reduced malaria morbidity and mortality in the
last two decades, although these reductions are now stalling. Significant efforts have been …

Gamete surface protein P48/45 has been shown to be important for male gamete fertility and
a strong candidate for the development of a malaria transmission-blocking vaccine (TBV) …

Chemical conjugation of polysaccharide to carrier proteins has been a successful strategy to
generate potent vaccines against bacterial pathogens. We developed a similar approach for …

The 6-cysteine protein family is one of the most abundant surface antigens that are
expressed throughout the Plasmodium falciparum life cycle. Many members of the 6 …

During their life cycle Plasmodium parasites rely upon an arsenal of proteins that establish
key interactions with the host and vector, and between the parasite sexual stages, with the …