Methadone is widely used for the treatment of opioid dependence. Although in most
countries the drug is administered as a racemic mixture of (R)-and (S)-methadone,(R) …

While opioid dependence has more treatment agents available than other abused drugs,
none are curative. They can, however, markedly diminish withdrawal symptoms and craving …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

Background and Objective Recent in vitro studies have suggested an important role of
cytochrome P450 (CYP) 2B6 and CYP2C19 in methadone metabolism. We aimed to …

Opioids have been used for centuries to treat a variety of psychiatric conditions with much
success. The so-called “opium cure” lost popularity in the early 1950s with the development …

Methadone, an opioid analgesic, is used clinically in pain therapy as well as for substitution
therapy in opioid addiction. It has a large interindividual variability in response and a narrow …

One consequence of repeated drug administration is the development of adaptations in the
nervous system, sometimes termed 'drug-opposite'responses. During administration, the …

Stereochemistry is now influencing most areas of pharmacotherapy, with a growing
awareness in the field of psychiatry and, more specifically, depression. This is due to the fact …

Background Radical surgery for colorectal cancer, associated with moderate to severe
postoperative pain, needs multimodal analgesia with opioid for analgesia. Despite …

Aim To construct a population pharmacokinetic model for methadone enantiomers in the
setting of methadone maintenance treatment for opioid dependence. Methods A population …