The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

In the search for interventions against aging and age-related diseases, biological screening
platforms are indispensable tools to identify anti-aging compounds among large substance …

Neuroinflammation is a central factor in neuropathic pain (NP). Ginger is a promising
bioactive compound in NP management due to its anti-inflammatory property. Emerging …

At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp).
Inhibitors targeting various effectors within the ERKp have been developed and explored for …

Fingolimod hydrochloride (FTY720) is a first‐in‐class of sphingosine‐1‐phosphate (S1P)
receptor modulator approved to treat multiple sclerosis by its phosphorylated form (FTY720 …

Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase
(MAPK) signaling pathway which allows the transduction of various cellular signals to final …

Matrine, one of the main alkaloid components extracted from the traditional Chinese herb,
Sophora flavescens Ait, has various pharmacological effects, and has been reported to exert …

The mitogen-activated protein kinase (MAPK)/ERK and phosphatidylinositol-3 kinase
(PI3K)/AKT pathways are dysregulated in various human cancers, including pancreatic …

The extracellular signal‐regulated kinase (ERK) MAPK pathway is dysregulated in various
human cancers and is considered an attractive therapeutic target for cancer. Therefore …

Abstract Heat shock factor 1 (HSF1) plays a central role in orchestrating the heat shock
response (HSR), leading to the activation of multiple heat shock proteins (HSPs) genes and …