In this review, we focus on progress that has been made with detecting small insertions and
deletions (INDELs) in human genomes. Over the past decade, several million small INDELs …

Advances in genome editing technologies have enabled manipulation of genomes at the
single base level. These technologies are based on programmable nucleases (PNs) that …

Nanopore sequencing of DNA is a single-molecule technique that may achieve long reads,
low cost and high speed with minimal sample preparation and instrumentation. Here, we …

Next-generation massively parallel sequencing technologies provide ultrahigh throughput at
two orders of magnitude lower unit cost than capillary Sanger sequencing technology. One …

Poly morphisms in mi cro R NAs (miRNAs) and their t arget s ites (PolymiRTS) are known to
disrupt miRNA function, leading to the development of disease and variation in physiological …

Although many studies have been conducted to identify single nucleotide polymorphisms
(SNPs) in humans, few studies have been conducted to identify alternative forms of natural …

The genetic structure of sheep reflects their domestication and subsequent formation into
discrete breeds. Understanding genetic structure is essential for achieving genetic …

We report the identification and characterization of 2,000 human diallelic insertion/deletion
polymorphisms (indels) distributed throughout the human genome. Candidate indels were …

We have developed a computer based method to identify candidate single nucleotide
polymorphisms (SNPs) and small insertions/deletions from expressed sequence tag data …

The near completeness of human chromosome sequences is facilitating accurate
characterization and assessment of all classes of genomic variation. Particularly, using the …