Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

The low probability of a drug candidate's clinical success, the time consumed and the high
cost of bringing a drug from concept to market emphasizes the need for new approaches to …

After a myocardial infarction, the boundary between the injured, hypoxic tissue and the
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …

While humans lack sufficient capacity to undergo cardiac regeneration following injury,
zebrafish can fully recover from a range of cardiac insults. Over the past two decades, our …

Tissue development and regeneration are dynamic processes involving complex cell
migration and cell-cell interactions. We have developed a protocol for complementary time …

Zebrafish are excellent at regenerating their heart by reinitiating proliferation in pre-existing
cardiomyocytes. Studying how zebrafish achieve this holds great potential in developing …

Endothelial cells emerge from the atrioventricular canal to form coronary blood vessels in
juvenile zebrafish hearts. We find that pdgfrb is first expressed in the epicardium around the …

Controlled electrical stimulation is essential for evaluating the physiology of cardiac tissues
engineered in heart-on-a-chip devices. However, existing stimulation techniques, such as …

Drug-induced nephrotoxicity is a leading cause of drug attrition, partly due to the limited
relevance of pre-clinical models of the proximal tubule. Culturing proximal tubule epithelial …

With heart failure continuing to become more prevalent, investigating the mechanisms of
heart injury and repair holds much incentive. In contrast with adult mammals, other …