Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

A Khan, M Ikram, JR Hahm, MO Kim - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders have emerged as a serious health issue in the current era.
The most common neurodegenerative disorders are Alzheimer's disease (AD), Parkinson's …

Toll‐Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease

L Wu, X Xian, G Xu, Z Tan, F Dong… - Mediators of …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease that primarily
manifests as memory deficits and cognitive impairment and has created health challenges …

Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-κB signaling

T Muhammad, M Ikram, R Ullah, SU Rehman, MO Kim - Nutrients, 2019 - mdpi.com
Glial activation and neuroinflammation play significant roles in apoptosis as well as in the
development of cognitive and memory deficits. Neuroinflammation is also a critical feature in …

Hesperetin confers neuroprotection by regulating Nrf2/TLR4/NF-κB signaling in an Aβ mouse model

M Ikram, T Muhammad, SU Rehman, A Khan… - Molecular …, 2019 - Springer
Hesperetin is a bioactive flavonoid in the body, produced from hesperidin. No
comprehensive studies have shown its protective effects in neurodegenerative disorders …

Flavonoids in modulation of cell survival signalling pathways

ML Mansuri, P Parihar, I Solanki, MS Parihar - Genes & nutrition, 2014 - Springer
Flavonoids, a family of polyphenols, generally found in various fruits and vegetables, as well
as in many plant beverages such as tea, pomegranate juice, raspberry, blueberries, and red …

Hesperetin induces apoptosis in breast carcinoma by triggering accumulation of ROS and activation of ASK1/JNK pathway

S Palit, S Kar, G Sharma, PK Das - Journal of cellular …, 2015 - Wiley Online Library
Hesperetin, a flavanone glycoside predominantly found in citrus fruits, exhibits a wide array
of biological properties. In the present study hesperetin exhibited a significant cytotoxic effect …

The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury

K Vafeiadou, D Vauzour, HY Lee… - Archives of Biochemistry …, 2009 - Elsevier
Neuroinflammation plays an integral role in the progression of neurodegeneration. In this
study we investigated the anti-inflammatory effects of different classes of flavonoids …

Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system

J Lee, DG Jo, D Park, HY Chung, MP Mattson… - Pharmacological …, 2014 - Elsevier
During the past 5 decades, it has been widely promulgated that the chemicals in plants that
are good for health act as direct scavengers of free radicals. Here we review evidence that …

Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

S Cirmi, N Ferlazzo, GE Lombardo… - Molecules, 2016 - mdpi.com
Neurodegenerative diseases (ND) result from the gradual and progressive degeneration of
the structure and function of the central nervous system or the peripheral nervous system or …

Polyphenols beyond barriers: a glimpse into the brain

I Figueira, R Menezes, D Macedo… - Current …, 2017 - ingentaconnect.com
Background: Ageing can be simply defined as the process of becoming older, which is
genetically determined but also environmentally modulated. With the continuous increase of …