Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the
discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9 …

Negative affective states are prevalent symptoms in a plethora of neuropsychiatric disorders,
including depression and drug addiction. Dysfunction of mesocorticolimbic dopamine …

The dynorphin/kappa opioid receptor (KOR) system is implicated in the “dark side” of
addiction, in which stress exacerbates maladaptive responses to drug and alcohol …

Chronic early-life stress increases vulnerability to alcoholism and anxiety disorders during
adulthood. Similarly, rats reared in social isolation (SI) during adolescence exhibit …

Pain remains a very pervasive problem throughout medicine. Classical pain management is
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …

Kappa opioid receptors (KORs) in the central nervous system have been known to be
important regulators of a variety of psychiatry illnesses, including anxiety and addiction, but …

Schizophrenia is a debilitating mental illness that affects approximately 1% of the world's
population. Despite much research in its neurobiology to aid in developing new treatments …

Opioid receptors belong to the class AG‐protein‐coupled receptors and are activated by
alkaloid opiates such as morphine, and endogenous ligands such as endorphins and …

There is significant need to find effective, nonaddictive pain medications. κ Opioid receptor
(KOPr) agonists have been studied for decades but have recently received increased …

Individual variation in the addiction liability of amphetamines has a heritable genetic
component. We previously identified Hnrnph1 (heterogeneous nuclear ribonucleoprotein …