Mechanisms of action of kefir in chronic cardiovascular and metabolic diseases

FS Pimenta, M Luaces-Regueira, AMM Ton… - Cellular Physiology and …, 2018 - karger.com
The gut microbiota maintains a complex mutual interaction with different organs of the host.
Whereas in normal conditions this natural community of trillions of microorganisms greatly …

The emerging scenario of the gut–brain axis: the therapeutic actions of the new actor kefir against neurodegenerative diseases

TMC Pereira, LZ Côco, AMM Ton, SS Meyrelles… - Antioxidants, 2021 - mdpi.com
The fact that millions of people worldwide suffer from Alzheimer's disease (AD) or
Parkinson's disease (PD), the two most prevalent neurodegenerative diseases (NDs), has …

Kidney intrinsic mechanisms as novel targets in renovascular hypertension

A Eirin, AR Chade, LO Lerman - Hypertension, 2024 - Am Heart Assoc
Almost a hundred years have passed since obstruction of the renal artery has been
recognized to raise blood pressure. By now chronic renovascular disease (RVD) due to …

Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension

AT Dias, BP Rodrigues, ML Porto, AL Gava… - Journal of translational …, 2014 - Springer
Background Oxidative stress and DNA damage have been implicated in the pathogenesis of
renovascular hypertension induced by renal artery stenosis in the two-kidney, one-clip …

The combination of G-CSF and AMD3100 mobilizes bone marrow-derived stem cells to protect against cisplatin-induced acute kidney injury in mice

Z Chen, X Ren, R Ren, Y Wang, J Shang - Stem cell research & therapy, 2021 - Springer
Background Several studies have confirmed that mobilizing bone marrow-derived stem cells
(BMSCs) ameliorates renal function loss following cisplatin-induced acute kidney injury …

Inhibition of phosphodiesterase 5 restores endothelial function in renovascular hypertension

AT Dias, AS Cintra, JC Frossard, Z Palomino… - Journal of translational …, 2014 - Springer
Background The clipping of an artery supplying one of the two kidneys (2K1C) activates the
renin-angiotensin (Ang) system (RAS), resulting in hypertension and endothelial …

Novel Therapeutic Targets for Phosphodiesterase 5 Inhibitors: current state-of-the-art on systemic arterial hypertension and atherosclerosis

EC Vasquez, AL Gava, JB Graceli… - Current …, 2016 - ingentaconnect.com
The usefulness of selective inhibitors of phosphodiesterase 5 (PDE5) is well known, first for
the treatment of male erectile dysfunction and more recently for pulmonary hypertension …

Resin from Virola oleifera Protects Against Radiocontrast-Induced Nephropathy in Mice

ISF Bôa, ML Porto, ACH Pereira, JPL Ramos… - PLoS …, 2015 - journals.plos.org
Contrast-induced nephropathy (CIN) is an iatrogenic medical event for which there is not yet
a successful therapy. Increasing evidence in rodents has suggested that this disease is …

The protective effect of G-CSF on experimental ischemia/reperfusion injury in rat ovary

MS Bostancı, M Bakacak, F Inanc, A Yaylalı… - Archives of gynecology …, 2016 - Springer
Objective This experimental study was designed to evaluate the effect of granulocyte colony-
stimulating factor (G-CSF) in ovarian ischemia and ischemia/reperfusion (I/R) injury. Study …

DNA Damage and Augmented Oxidative Stress in Bone Marrow Mononuclear Cells from Angiotensin‐Dependent Hypertensive Mice

BP Campagnaro, CL Tonini… - International Journal …, 2013 - Wiley Online Library
It has been proposed that the nonhemodynamic effects of angiotensin II are important for the
damage observed in the two‐kidney, one‐clip (2K1C) renovascular hypertension model …