CB1 and CB2 receptors are activated by a plethora of cannabinoid compounds, be they
endogenously‐produced, plant‐derived or synthetic. These receptors are expressed by …

After their discovery, the two known cannabinoid receptors, CB1 and CB2, have been the
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …

After the discovery, in the early 1990s, of specific G‐protein‐coupled receptors for
marijuana's psychoactive principle Δ9‐tetrahydrocannabinol, the cannabinoid receptors …

Cannabinoids exert pleiotropic actions in the CNS, including the inhibition of inflammatory
responses and the enhancement of neuronal survival after injury. Although cannabinoid …

Growing evidence suggests that a major physiological function of the cannabinoid signaling
system is to modulate neuroinflammation. This review discusses the anti‐inflammatory …

Cannabinoid receptors and their endogenous ligands constitute a novel modulatory system
that is involved in specific brain functions, such as nociception, control of movement …

The presence of central cannabinoid receptor (CB1), involving the N-terminal 14 amino acid
peptide, was demonstrated in the rat brain by immunohistochemistry. Intensely stained …

Cannabinoids and opioids are widely consumed drugs of abuse that produce motor
depression, in part via respective activation of the cannabinoid subtype 1 receptor (CB1R) …

Anandamide [arachidonylethanolamide (AEA)] appears to be an endogenous agonist of
brain cannabinoid receptors (CB1), yet some of the neurobehavioral effects of this …

The molecular mechanism of action of Δ 9-tetrahydrocannabinol (THC), the psychotropic
constituent of Cannabis, has been a puzzle during the three decades separating its …