The recent cataloging of the genomic aberrations in breast cancer has revealed the diversity
and complexity of the disease at the genetic level. To unravel the functional consequences …

An increasing number of tumors, including breast cancer, overexpress proteins of the
epidermal growth factor receptor (EGFR) family. The interaction between family members …

SARS-CoV-2 infection is characterized by peak viral load in the upper airway prior to or at
the time of symptom onset, an unusual feature that has enabled widespread transmission of …

FAM83B (family with sequence similarity 83, member B) was recently identified as a novel
oncogene involved in activating CRAF/MAPK signaling and driving epithelial cell …

Metastasis and tumor progression are the major cause of death in patients suffering from
pancreatic ductal adenocarcinoma. Tumor growth and especially dissemination are typically …

The development of novel targeted therapies for cancer treatment requires identification of
reliable targets. FAM 83 ('family with sequence similarity 83') family members A, B, and D …

Abnormal activation of Wnt/β-catenin-mediated transcription is closely associated with the
malignancy of pancreatic cancer. Family with sequence similarity 83 member A (FAM83A) …

Background HER2 is overexpressed and amplified in approximately 15% of invasive breast
cancers, and is the molecular target and predictive marker of response to anti-HER2 agents …

Members of the casein kinase 1 (CK1) family of serine-threonine protein kinases are
implicated in the regulation of many cellular processes, including the cell cycle, circadian …

Epidermal growth factor receptor (EGFR) and human EGFR 2 (HER2) have an important
role in the initiation and progression of various types of cancer. Inhibitors targeting these …