Supercritical fluid technology: an emphasis on drug delivery and related biomedical applications

RK Kankala, YS Zhang, SB Wang… - Advanced …, 2017 - Wiley Online Library
During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

Supercritical fluids for pharmaceutical particle engineering: Methods, basic fundamentals and modelling

A Tabernero, EMM del Valle, MA Galán - Chemical Engineering and …, 2012 - Elsevier
The interest of the use of supercritical fluids, especially supercritical CO2, for particle
engineering over the last years has received attention from the pharmaceutical industry …

Supercritical fluid (SCF)-assisted fabrication of carrier-free drugs: an eco-friendly welcome to active pharmaceutical ingredients (APIs)

RK Kankala, PY Xu, BQ Chen, SB Wang… - Advanced Drug Delivery …, 2021 - Elsevier
Despite the success in developing various pharmaceutical formulations, most of the active
pharmaceutical ingredients (APIs)/drugs, according to the Biopharmaceutics Classification …

Phase transition enthalpy measurements of organic and organometallic compounds and ionic liquids. Sublimation, vaporization, and fusion enthalpies from 1880 to …

W Acree, JS Chickos - Journal of Physical and Chemical Reference …, 2017 - pubs.aip.org
This compendium completes a previous report published in 2016 [2016ACR/CHI] on phase
change enthalpies. Paper I of this compendium includes over 6600 organic compounds …

Amorphization of drugs by adsorptive precipitation from supercritical solutions: A review

P Gurikov, I Smirnova - The journal of supercritical fluids, 2018 - Elsevier
In this review, available experimental data on the drug confinement in porous matrices via
adsorptive precipitation from supercritical fluid solutions with a special emphasis on the drug …

Are pharmaceutics really going supercritical?

I Pasquali, R Bettini - International journal of pharmaceutics, 2008 - Elsevier
The present work focuses on some applications of supercritical fluids in the pharmaceutical
field, provides a critical review of the most recent advances and aims to give a vision on the …

Manufacture of submicron drug particles with enhanced dissolution behaviour by rapid expansion processes

M Türk - The Journal of Supercritical Fluids, 2009 - Elsevier
In the case of pharmaceutical substances the particle size is quite important since it can limit
the bioavailability of poorly soluble drugs. As an example we can refer to the data obtained …

Advanced technologies for oral controlled release: cyclodextrins for oral controlled release

PJ Salústio, P Pontes, C Conduto, I Sanches… - Aaps Pharmscitech, 2011 - Springer
Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion
complexes formation, with the following advantages for the drugs:(1) solubility, dissolution …

Supercritical carbon dioxide processing of active pharmaceutical ingredients for polymorphic control and for complex formation

K Moribe, Y Tozuka, K Yamamoto - Advanced Drug Delivery Reviews, 2008 - Elsevier
Supercritical fluid technique have been exploited in extraction, separation and crystallization
processes. In the field of pharmaceutics, supercritical carbon dioxide (scCO2) has been …

Physicochemical properties of antifungal drug–cyclodextrin complexes prepared by supercritical carbon dioxide and by conventional techniques

AH Al-Marzouqi, HM Elwy, I Shehadi, A Adem - Journal of pharmaceutical …, 2009 - Elsevier
Antifungal drugs are the most common systemic drugs used for the treatment of
oropharyngeal candidiasis, which is the first symptom of HIV infection. However, the efficacy …