Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function
Increasing evidence indicates close interaction between immune cells and the brain,
revising the traditional view of the immune privilege of the brain. However, the specific …
revising the traditional view of the immune privilege of the brain. However, the specific …
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis
KT Evans, K Blake, A Longworth, MA Coburn… - Nature Cell …, 2023 - nature.com
Breast cancer brain metastasis (BCBM) is a lethal disease with no effective treatments. Prior
work has shown that brain cancers and metastases are densely infiltrated with anti …
work has shown that brain cancers and metastases are densely infiltrated with anti …
Microglia in a dish—which techniques are on the menu for functional studies?
P Aktories, P Petry, K Kierdorf - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Microglia build the first line of defense in the central nervous system (CNS) and play central
roles during development and homeostasis. Indeed, they serve a plethora of diverse …
roles during development and homeostasis. Indeed, they serve a plethora of diverse …
Targeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia/macrophages and promotes long-term recovery after …
Background Brain microglia and macrophages (Mi/MΦ) can shift to a harmful or
advantageous phenotype following an ischemic stroke. Identification of key molecules that …
advantageous phenotype following an ischemic stroke. Identification of key molecules that …
Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice
Elderly patients with traumatic brain injury (TBI) have greater mortality and poorer outcomes
than younger individuals. The extent to which old age alters long-term recovery and chronic …
than younger individuals. The extent to which old age alters long-term recovery and chronic …
[HTML][HTML] Translatomic response of retinal Müller glia to acute and chronic stress
Abstract Analysis of retina cell type-specific epigenetic and transcriptomic signatures is
crucial to understanding the pathophysiology of retinal degenerations such as age-related …
crucial to understanding the pathophysiology of retinal degenerations such as age-related …
Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Nonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to
hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators …
hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators …
Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans
Major histocompatibility complex I (MHC-I) CNS cellular localization and function is still
being determined after previously being thought to be absent from the brain. MHC-I …
being determined after previously being thought to be absent from the brain. MHC-I …
Comparative analysis of methods to reduce activation signature gene expression in PBMCs
Preserving the in vivo cell transcriptome is essential for accurate profiling, yet factors during
cell isolation including time ex vivo and temperature induce artifactual gene expression …
cell isolation including time ex vivo and temperature induce artifactual gene expression …