The sickle hemoglobin (HbS) point mutation has independently undergone evolutionary
selection at least five times in the world because of its overwhelming malarial protective …

Sickle cell disease (SCD) is the most common inherited disease in the world. Red blood cell
sickling, blood cell-endothelium adhesion, blood rheology abnormalities, intravascular …

This document provides a roadmap for policy considerations regarding health and safety
concerns for secondary school athletes. Although these guidelines are not exhaustive for all …

Background Studies have suggested that sickle cell trait elevates the risks of exertional
rhabdomyolysis and death. We conducted a study of sickle cell trait in relation to these …

Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR),
contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide …

Worldwide, sickle cell trait is a highly prevalent gene carrier state. While generally a benign
condition with a normal life expectancy, it is becoming increasingly clear that the sickle trait …

Abstract Development of exercise guidelines for individuals with sickle cell trait (SCT) and
sickle cell anemia (SCA) is hampered by the need to weigh the benefits against risks of …

Sickle cell trait has long been considered a benign condition but continues to be the leading
cause of death in young African Americans in military basic training and civilian organized …

The complications of sickle cell disease (SCD) arise from the presence in red cells of the
mutated haemoglobin, HbS, which replaces the normal adult Hb, HbA. HbS has a single …

Context: Sports medicine providers frequently return athletes to play after sports-related
injuries and conditions. Many of these conditions have guidelines or medical evidence to …