The only known function of oligodendrocytes is to myelinate axons in the vertebrate CNS. In
this review, we consider how the number of oligodendrocytes is matched during …

The energetics of CNS white matter are poorly understood. We derive a signaling energy
budget for the white matter (based on data from the rodent optic nerve and corpus callosum) …

We have identified a cell type in 7-day-old rat optic nerve that differentiates into a fibrous
astrocyte if cultured in the presence of fetal calf serum and into an oligodendrocyte if …

Maternal alcohol abuse during pregnancy causes malformations of the eyes with serious
consequences to the vision of the affected children. A high percentage (up to 90%) of …

The signaling mechanisms that control the survival of CNS neurons are poorly understood.
Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal …

The development of most regions of the vertebrate nervous system includes a distinct phase
of neuronal degeneration during which a substantial proportion of the neurons initially …

Two different monoclonal antibodies to the Thy-l antigen, TllD7 and 2Gl2, were used to
purify and characterize retinal ganglion cells from postnatal rat retina. Although Thy-l has …

ABSTRACT A key event in the development of the mammalian cerebral cortex is the
generation of neuronal populations during embryonic life. Previous studies have revealed …

A central hypothesis of neural development is that patterned activity drives the refinement of
initially imprecise connections. We have examined this hypothesis directly by altering the …

The number of ganglion cells in the retina of the postnatal rat has been examined. We
estimated both the number of axons in the optic nerve and the number of cells which can be …