Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context …

Since the discovery of the major excitatory and inhibitory neurotransmitters and their
receptors in the brain, many have deliberated over their likely structures and how these may …

Protein cavities and tunnels are critical in determining phenomena such as ligand binding,
molecular transport, and enzyme catalysis. Molecular dynamics (MD) simulations enable the …

We present a full-length α1β2γ2 GABA receptor model optimized for agonists and
benzodiazepine (BZD) allosteric modulators. We propose binding hypotheses for the …

Nicotinic acetylcholine receptors (AChRs) are one of the best characterized ion channels
from the Cys-loop receptor superfamily. The study of acetylcholine binding proteins and …

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation-conducting
transmembrane channels from the cys-loop receptor superfamily. The neuronal subtypes of …

The recent introduction of the chloronicotinyl insecticide imidacloprid, targeting insect
nicotinic acetylcholine receptors (nAChRs), emphasises the importance of a detailed …

GABAA receptors (GABAARs) are ligand gated chloride ion channels that mediate overall
inhibitory signaling in the CNS. A detailed understanding of their structure is important to …

The cys-loop receptors are neurotransmitter-operated ion channels, which mediate fast
synaptic transmission for communication between neurons. However, prolonged exposure …