Beyond pore formation: Reorganization of the plasma membrane induced by pore-forming proteins

M Kulma, G Anderluh - Cellular and Molecular Life Sciences, 2021 - Springer
Pore-forming proteins (PFPs) are a heterogeneous group of proteins that are expressed and
secreted by a wide range of organisms. PFPs are produced as soluble monomers that bind …

Switchable Zinc (II)-Responsive Globular β-Sheet Peptide

TL Pham, M Kovermann, F Thomas - ACS Synthetic Biology, 2021 - ACS Publications
The natural function of many proteins depends on their ability to switch their conformation
driven by environmental changes. In this work, we present a small, monomeric β-sheet …

Effect of lipid oxidation on the channel properties of Cx26 hemichannels: a molecular dynamics study

MC Oliveira, RM Cordeiro, A Bogaerts - Archives of Biochemistry and …, 2023 - Elsevier
Intercellular communication plays a crucial role in cancer, as well as other diseases, such as
inflammation, tissue degeneration, and neurological disorders. One of the proteins …

Correlation between CNS Tuberculosis and the COVID-19 pandemic: the neurological and therapeutic insights

N Mandal, N De, P Jana, A Sannigrahi… - ACS Chemical …, 2020 - ACS Publications
The recent outbreak of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)
from Wuhan, China, was caused by a single-stranded RNA virus which has kept the entire …

Leveraging Flavonoids as Potential Inhibitors of METTL3 in Combating Cancer: A Combined Structure‐Based Drug Design and DFT Approach

NE Abo‐Dya, AR Issahaku - ChemistrySelect, 2023 - Wiley Online Library
Abstract Methyltransferase‐like 3 (METTL3) serves as a primary catalytic enzyme within the
N6‐methyladenosine (m6 A) methyltransferase system, playing a crucial role in various …

Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

J Luo, J Ranish - Elife, 2024 - elifesciences.org
Dynamic conformational and structural changes in proteins and protein complexes play a
central and ubiquitous role in the regulation of protein function, yet it is very challenging to …