De novo protein design is a longstanding fundamental goal of synthetic biology, but has
been hindered by the difficulty in reliable prediction of accurate high-resolution protein …

Nature provides a large number of functional proteins that evolved during billions of years of
evolution. The diversity of natural proteins encompasses versatile functions and more than a …

Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR–Cas technologies.
However, the available Acr repertoire is limited to naturally occurring variants. Here, we …

The development of mimetic antibodies (MA) capable of combining the high affinity and
selectivity of antibodies with the small size of the peptides has enormous potential for …

De novo protein design has enabled the creation of novel protein structures. To design
novel functional proteins, state-of-the-art approaches use natural proteins or first design …