Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

5-Lipoxygenase (5-LO) plays a vital role in the host innate immune response, including
bacteria-induced inflammation. Apical periodontitis (AP) is due to immune disorders caused …

Staphylococcus aureus causes severe infections associated with inflammation, such as
sepsis or osteomyelitis. Inflammatory processes are regulated by distinct lipid mediators …

Osteoporosis is one of the most common diseases worldwide. In osteoporosis, vertebral
fractures represent a major burden. Lipoxygenase (LOX) inhibitors such as baicalein and …

Objectives This study aimed to clarify the expression profile and significance of
lipoxygenases in periodontitis. Materials and Methods The mRNA levels of lipoxygenases in …

Objective To analyze the lack of 5-lipoxygenase (5LO) on dental socket healing and post-
natal phenotype of intramembranous and endochondral bones. Design Wild type (WT) …

Estrogen deficiency and aging are associated with osteoporosis, impaired bone healing,
and lower cognitive performance. Close functional and physical connections occur between …

Background Osteoporosis is one of the world's major medical burdens in the twenty-first
century. Pharmaceutical intervention currently focusses on decelerating bone loss, but …

Background In previous studies, we reported the beneficial impact of two lipoxygenase-
inhibitors, Baicalein and Zileuton, on osteoporotic bone in a postmenopausal rat model …

This study investigated the role 5-lypoxigenase (5-LO) on alveolar socket healing in aged
female mice treated with zoledronic acid (ZL). Forty 129/Sv female mice (64–68 weeks old) …