Abstract Background The Nuclear Factor kappaB (NF-kB) family consists of transcription
factors that play a complex and essential role in the regulation of immune responses and …

This article reviews recent progress in research on the role of Smad signaling in corneal
wound healing. Smad2 and Smad3 are key signaling molecules downstream of the cell …

purpose. The purpose of the present study was to examine the roles of signaling pathways
potentially activated by TGFβ (ie, Smad and p38 mitogen-activated kinase [MAPK]) in …

Necrotizing enterocolitis (NEC) seems to result from the inflammatory response of an
immature intestine. Human milk is protective against NEC via an unknown mechanism. We …

Cervical cancer is the major cause of cancer related deaths in women, especially in
developing countries and Human Papilloma Virus infection in conjunction with multiple …

We have investigated transforming growth factor beta (TGF-β)–mediated induction of actin
stress fibers in normal and metastatic epithelial cells. We found that stress fiber formation …

Abstract Purpose and Experimental Design: The mutational spectrum of MADH4
(DPC4/SMAD4) opens valuable insights into the functions of this protein that confer its tumor …

Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine that plays important
roles in cervical tumor formation, invasion, progression, and metastasis. TGF-β1 functions as …

The transforming growth factor-β (TGF-β) signalling pathway participates in various
biological processes. Dysregulation of Smad4, a central cellular transducer of TGF-β …

As the incidence and the mortality rate of head and neck squamous cell carcinoma
(HNSCC) is increasing worldwide, gaining knowledge about the genomic changes which …