The vertebrate transcription factor NF-κB is induced by over 150 different stimuli. Active NF-
κB, in turn, participates in the control of transcription of over 150 target genes. Because a …

Matricellular proteins are components of the extracellular matrix which are highly expressed
in the developing and mature skeleton. Members of this protein class serve as biological …

The transcription factor NF-κB is activated in a range of human cancers and is thought to
promote tumorigenesis, mainly due to its ability to protect transformed cells from apoptosis …

Abstract Thrombospondin-2 (TSP2) and osteonectin/BM-40/SPARC are matricellular
proteins that are highly expressed by bone cells. Mice deficient in either of these proteins …

Abstract p53 tumor suppressor gene controls cell response to a variety of stresses inducing
growth arrest or apoptosis in damaged cells. It largely determines the sensitivity of tumor and …

Increasing evidence suggests critical functions of thrombospondins (TSPs) in a variety of
physiological and pathological processes. With the growing understanding of the …

The tumor-suppressor gene p53 and its downstream genes consist of a complicated gene
network. p53 is a key molecular node in the network, which is activated in response to …

Background Identifying biomarkers may lead to easier detection and a better understanding
of pathogenesis of pancreatic ductal adenocarcinoma (PDAC). Methods Plasma small …

The prostate cancer (PCa) microenvironment contains active stromal cells known as cancer-
associated fibroblasts (CAF) that may play important roles in influencing tumor progression …

Impaired wound healing is a major complication of diabetes, and despite the associated
risks, treatment strategies for diabetic wounds remain limited. This is due, in part, to an …