Transposable elements shape the evolution of mammalian development
AD Senft, TS Macfarlan - Nature Reviews Genetics, 2021 - nature.com
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Mechanisms of early placental development in mouse and humans
The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
Self-patterning of human stem cells into post-implantation lineages
Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …
and ethical limitations of working with embryonic samples. In the face of these difficulties …
An in vitro model of early anteroposterior organization during human development
The body plan of the mammalian embryo is shaped through the process of gastrulation, an
early developmental event that transforms an isotropic group of cells into an ensemble of …
early developmental event that transforms an isotropic group of cells into an ensemble of …
The cytoplasmic DNA sensor cGAS promotes mitotic cell death
Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-
stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional …
stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional …
A 3D model of a human epiblast reveals BMP4-driven symmetry breaking
Breaking the anterior–posterior symmetry in mammals occurs at gastrulation. Much of the
signalling network underlying this process has been elucidated in the mouse; however …
signalling network underlying this process has been elucidated in the mouse; however …
Self-organization of stem cells into embryos: a window on early mammalian development
Embryonic development is orchestrated by robust and complex regulatory mechanisms
acting at different scales of organization. In vivo studies are particularly challenging for …
acting at different scales of organization. In vivo studies are particularly challenging for …
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …
Distinct pathways drive anterior hypoblast specification in the implanting human embryo
Abstract Development requires coordinated interactions between the epiblast, which
generates the embryo proper; the trophectoderm, which generates the placenta; and the …
generates the embryo proper; the trophectoderm, which generates the placenta; and the …
A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells
Long-range signaling by morphogens and their inhibitors define embryonic patterning yet
quantitative data and models are rare, especially in humans. Here, we use a human …
quantitative data and models are rare, especially in humans. Here, we use a human …