Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

In moving towards the simulation of larger nucleic acid assemblies over longer timescales
that include more accurate representations of the environment, we are nearing the end of an …

Antibiotic resistance is now a major threat to human health, and one approach to combating
this threat is to develop resistance-resistant antibiotics. Synthetic antimicrobial polymers are …

Parasitic protozoa comprise diverse aetiological agents responsible for important diseases
in humans and animals including sleeping sickness, Chagas disease, leishmaniasis …

Fluorescence microscopy of trypanosomes from drug treated mice shows that biologically
active heterocyclic diamidines that target the DNA minor groove bind rapidly and specifically …

Binding of Rhodamine B to Calf thymus DNA (CT DNA) was studied using various
biophysical techniques and molecular docking method. Circular dichroic studies revealed …

Targeting the minor groove of DNA through binding to a small molecule has long been
considered an important molecular-recognition strategy in biology. A wide range of synthetic …

The year 2004 represents a milestone for the biosensor research community: in this year,
over 1000 articles were published describing experiments performed using commercially …

Nucleic acids are polyanionic molecules that were historically considered to be solely
surrounded by a shell of water molecules and a neutralizing cloud of monovalent and …

Parasitic infections are widespread in developing countries and frequently associated with
immunocompromised patients in developed countries. Consequently, such infections are …