Growing evidence supports the pivotal role played by oxidative stress in tissue injury
development, thus resulting in several pathologies including cardiovascular, renal …

Neuroinflammation is a complex process involved in the physiophatology of many central
nervous system diseases, including addiction. Alcohol abuse is characterized by induction …

Inhibition of Ca 2+ entry into the hippocampus and dorsal root ganglion (DRG) through
inhibition of N-methyl-d-aspartate (NMDA) receptor antagonist drugs is the current standard …

Chronic cerebral hypoperfusion (CCH) has been considered as a critical cause for the
development of cognitive decline and dementia of vascular origin. Melatonin receptors have …

Sciatic nerve injury (SNI) results in neuropathic pain, which is characterized by the
excessive Ca2+ entry, reactive oxygen species (ROS) and apoptosis processes although …

Background: Transient receptor potential (TRP) channels are a superfamily of ion channels
termed after the trp gene in Drosophila that are diverse in structure and control a wide range …

Alzheimer's disease (AD) is the most common cause of progressive cognitive impairment in
the aged. The aggregation of the amyloid β-protein (Aβ) is a hallmark of AD and is linked to …

Huntington׳ s disease (HD), a devastating neurodegenerative disorder, is characterized by
weight loss, impairment of motor function, cognitive dysfunction, neuropsychiatric …

Alzheime's disease (AD) is an overwhelming neurodegenerative disorder, characterized by
synaptic dysfunction, memory loss, neuro-inflammation and neural cell death. Very few …

Dementia is a major cause of disability and dependency among older people. If the lives of
people with dementia are to be improved, research and its translation into druggable target …