Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …

Clostridioides difficile infection (CDI) remains an urgent global One Health threat. The
genetic heterogeneity seen across C. difficile underscores its wide ecological versatility and …

While the field of microbial biogeography has largely focused on the contributions of abiotic
factors to community patterns, the potential influence of biotic interactions in structuring …

Microbial genome mining for drug discovery and development has been accelerating in
recent years, driven by technical advancements in genome sequencing, bioinformatics …

One of the most important ways that bacteria compete for resources and space is by
producing antibiotics that inhibit competitors. Because antibiotic production is costly, the …

Soil microbial diversity is often studied from the perspective of community composition, but
less is known about genetic heterogeneity within species. The relative impacts of clonal …

Covering: up to 2021 Natural products research is in the midst of a renaissance ushered in
by a modern understanding of microbiology and the technological explosions of genomics …

For decades, scientists have conducted bioprospecting on Actinobacteria for the discovery
of novel genera producing bioactive metabolites (Atalan et al., 2000; Bull et al., 2000; …

The diversity and distribution of specialized metabolite gene clusters within a community of
bacteria living in the same soil habitat are poorly documented. Here we analyzed the …