This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …

Cachexia is a systemic condition that occurs during many neoplastic diseases, such as
cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by …

Irisin is a hormone‐like myokine produced in abundance by skeletal muscle in response to
exercise, both in mice and humans. Once released into the circulation, irisin acts on white …

Research investigators have shown a growing interest in investigating alterations underlying
skeletal muscle wasting in patients with cancer. However, skeletal muscle dysfunctions …

Alterations in amino acid and protein metabolism—particularly in skeletal muscle—are a key
feature of cancer that contributes to the cachexia syndrome. Thus, skeletal muscle protein …

Chemotherapy is frequently accompanied by several side effects, including nausea,
diarrhea, anorexia and fatigue. Evidence from ours and other groups suggests that …

Abstract Purpose of Review To summarize the fundamental role of transforming growth
factor beta (TGFβ) signaling in osteocytes and highlight the physiological and …

Breast cancer and its therapies frequently result in significant musculoskeletal morbidity.
Skeletal complications include bone metastases, pain, bone loss, osteoporosis, and fracture …

Regular physical exercise and a healthy diet are major determinants of a healthy lifespan.
Although aging is associated with declining endurance performance and muscle function …

Osteosarcopenia is a burgeoning geriatric syndrome and a familiar disease among older
individuals. It is characterized by reduced skeletal muscle mass and bone mineral density …