The effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis

A Narmashiri, M Abbaszadeh, A Ghazizadeh - … & Biobehavioral Reviews, 2022 - Elsevier
Memory and motor deficits are commonly identified in Parkinson's disease (PD). 1-Methyl-4-
phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is transformed to MPP+ via monoamine oxidase …

Anxiety in Parkinson's disease: a critical review of experimental and clinical studies

RDS Prediger, FC Matheus, ML Schwarzbold… - …, 2012 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting
about 1% of the population older than 60 years. Classically, PD is considered as a …

A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18

P Bossù, D Cutuli, I Palladino, P Caporali… - Journal of …, 2012 - Springer
Background Systemic inflammation might cause neuronal damage and sustain
neurodegenerative diseases and behavior impairment, with the participation of pro …

[PDF][PDF] Current understanding of the neurobiology of major depressive disorder

AL Chiriţă, V Gheorman, D Bondari, I Rogoveanu - Rom J Morphol Embryol, 2015 - rjme.ro
Depression is highly prevalent worldwide and associated with significant morbidity and
mortality. Approximately 340 million people worldwide suffer from depression at any given …

Toxin-induced experimental models of learning and memory impairment

SV More, H Kumar, DY Cho, YS Yun… - International journal of …, 2016 - mdpi.com
Animal models for learning and memory have significantly contributed to novel strategies for
drug development and hence are an imperative part in the assessment of therapeutics …

On the modulatory roles of neuregulins/ErbB signaling on synaptic plasticity

A Ledonne, NB Mercuri - International Journal of Molecular Sciences, 2019 - mdpi.com
Neuregulins (NRGs) are a family of epidermal growth factor-related proteins, acting on
tyrosine kinase receptors of the ErbB family. NRGs play an essential role in the development …

Transcranial ultrasound stimulation suppresses neuroinflammation in a chronic mouse model of Parkinson's disease

H Zhou, L Meng, X Xia, Z Lin, W Zhou… - IEEE Transactions …, 2021 - ieeexplore.ieee.org
Objective: Neuroinflammation contributes to the development and progression of
Parkinson's disease (PD). The aim of this study was to examine whether ultrasound (US) …

Sex-specific enhanced behavioral toxicity induced by maternal exposure to a mixture of low dose endocrine-disrupting chemicals

M Sobolewski, K Conrad, JL Allen, H Weston, K Martin… - Neurotoxicology, 2014 - Elsevier
Humans are increasingly and consistently exposed to a variety of endocrine disrupting
chemicals (EDCs), chemicals that have been linked to neurobehavioral disorders such as …

Neuropsychiatric disorders in Parkinson's disease: what do we know about the role of dopaminergic and non-dopaminergic systems?

K Dujardin, V Sgambato - Frontiers in neuroscience, 2020 - frontiersin.org
Besides the hallmark motor symptoms (rest tremor, hypokinesia, rigidity, and postural
instability), patients with Parkinson's disease (PD) have non-motor symptoms, namely …

Understanding cognitive deficits in Parkinson's disease: lessons from preclinical animal models

N Solari, A Bonito-Oliva, G Fisone… - Learning & …, 2013 - learnmem.cshlp.org
Parkinson's disease (PD) has been, until recently, mainly defined by the presence of
characteristic motor symptoms, such as rigidity, tremor, bradykinesia/akinesia, and postural …