Effects of aging on fracture healing

D Clark, M Nakamura, T Miclau, R Marcucio - Current osteoporosis reports, 2017 - Springer
Abstract Purpose of Review This review summarizes research on the physiological changes
that occur with aging and the resulting effects on fracture healing. Recent Findings Aging …

[HTML][HTML] Major depression and the biological hallmarks of aging

EC Lorenzo, GA Kuchel, CL Kuo, TE Moffitt… - Ageing research …, 2023 - Elsevier
Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …

Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

Y Jiang, AA Trotsyuk, S Niu, D Henn, K Chen… - Nature …, 2023 - nature.com
Abstract 'Smart'bandages based on multimodal wearable devices could enable real-time
physiological monitoring and active intervention to promote healing of chronic wounds …

[HTML][HTML] Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways

S Ren, J Chen, D Duscher, Y Liu, G Guo… - Stem Cell Research & …, 2019 - Springer
Background Human adipose stem cells (ASCs) have emerged as a promising treatment
paradigm for skin wounds. Recent works demonstrate that the therapeutic effect of stem cells …

Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

Q Lei, F Gao, T Liu, W Ren, L Chen, Y Cao… - Science translational …, 2021 - science.org
Stem cell senescence increases alongside the progressive functional declines that
characterize aging. The effects of extracellular vesicles (EVs) are now attracting intense …

Age-related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development

P Ganguly, JJ El-Jawhari, PV Giannoudis… - Cell …, 2017 - journals.sagepub.com
Aging at the cellular level is a complex process resulting from accumulation of various
damages leading to functional impairment and a reduced quality of life at the level of the …

Stem cells in wound healing: the future of regenerative medicine? A mini-review

D Duscher, J Barrera, VW Wong, ZN Maan, AJ Whittam… - Gerontology, 2016 - karger.com
The increased risk of disease and decreased capacity to respond to tissue insult in the
setting of aging results from complex changes in homeostatic mechanisms, including the …

[HTML][HTML] Usage of human mesenchymal stem cells in cell-based therapy: advantages and disadvantages

HJ Kim, JS Park - Development & reproduction, 2017 - ncbi.nlm.nih.gov
The use of human mesenchymal stem cells (hMSCs) in cell-based therapy has attracted
extensive interest in the field of regenerative medicine, and it shows applications to …

[HTML][HTML] Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research

L Lopes, O Setia, A Aurshina, S Liu, H Hu… - Stem cell research & …, 2018 - Springer
Background Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most
diabetes-related amputations. DFUs require over US $9 billion for yearly treatment and are …

Mesenchymal stem cells (MSC) derived from induced pluripotent stem cells (iPSC) equivalent to adipose-derived MSC in promoting intestinal healing and microbiome …

S Soontararak, L Chow, V Johnson… - Stem cells …, 2018 - academic.oup.com
Cellular therapy with allogeneic or autologous mesenchymal stem cells (MSC) has emerged
as a promising new therapeutic strategy for managing inflammatory bowel disease (IBD) …