As one of the most common metastatic sites of malignancies, bone has a unique
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …

Extracellular acidosis is associated with various immunopathological states. The
microenvironment of numerous solid tumours and inflammatory responses during acute or …

The pre-metastatic niche has been shown to play a critical role in tumor metastasis, and its
formation is closely related to the tumor microenvironment. However, the underlying …

Tumors and neutrophils undergo an unexpected interaction, in which products released by
tumor cells interact to support neutrophils that in turn support cancer growth, angiogenesis …

Abstract Vacuolar-type H+-ATPases (V-ATPases) are large multi-subunit complexes that
play critical roles in the acidification of a variety of intracellular or extracellular …

Introduction Bone metastasis (BoM) occurs when cancer cells spread from their primary sites
to a bone. Currently, the mechanism underlying this metastasis process remains unclear …

Solid tumors comprise two major components: the cancer cells and the tumor stroma. The
stroma is a mixture of cellular and acellular components including fibroblasts, mesenchymal …

Vascular remodeling within the uterus immediately before and during early pregnancy
increases blood flow in the fetus and prevents the development of gestational hypertension …

Bone metastasis of cancer is a common process that destroys the balance between
osteoclast and osteoblast, causing skeletal-related events. Cancer bone metastasis is a …

Remodeling of the uterine spiral arteries (UtA) during pregnancy allows for increased blood
flow to the fetus and prevents the development of gestational hypertension despite a 50 …