Importance Cirrhosis affects approximately 2.2 million adults in the US. From 2010 to 2021,
the annual age-adjusted mortality of cirrhosis increased from 14.9 per 100 000 to 21.9 per …

Non-alcoholic fatty liver disease (NAFLD) is projected to become the leading cause of
hepatocellular carcinoma (HCC) in many countries. Many risk factors for NAFLD are also …

Conclusions Our findings indicate that LINC00665 is involved in the NF‐κB signaling
activation in HCC cells and that the inflammatory LINC00665/PKR/NF‐κB loop plays …

Background Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in
this paper) are a major cause of morbidity and mortality globally, although the burden and …

Background & Aims Accurate estimates for the contemporary burden of chronic liver disease
(CLD) are vital for setting clinical, research, and policy priorities. We aimed to review the …

Introduction Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third-
leading cause of cancer-related mortality in the world. Areas covered This review will …

Alcohol-associated liver disease (ALD) represents a spectrum of liver injury resulting from
alcohol use, ranging from hepatic steatosis to more advanced forms including alcoholic …

Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due
to complications of cirrhosis and 1 million due to viral hepatitis and hepatocellular …

The obesity epidemic is closely associated with the rising prevalence and severity of
nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple …

Background & Aims Estimates of disease burden can inform national health priorities for
research, clinical care, and policy. We aimed to estimate health care use and spending …