Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

Histone deacetylases (HDACs) are a group of enzymes that catalyze the removal of acetyl
groups from histone and nonhistone proteins. HDACs have been shown to have diverse …

Highlights•Enucleation is a rate-limiting step in erythropoiesis that leads to the formation of
RBCs.•Regulators of enucleation range from transcription factors to miRNAs.•Optimum …

Abstract Inverted formin 2 (INF2) is a member of the formin family of actin assembly factors.
Dominant missense mutations in INF2 are linked to two diseases: focal segmental …

Reversible lysine acetylation of nuclear proteins such as histones is a long-established
important regulatory mechanism for chromatin remodeling and transcription. In the …

Red blood cells, or erythrocytes, make up approximately a quarter of all cells in the human
body with over 2 billion new erythrocytes made each day in a healthy adult human. This …

Erythropoiesis is a process of enormous magnitude, with the average person generating two
to three million red cells every second. Erythroid progenitors start as large cells with large …

Numerous studies have highlighted the role of post-translational modifications in the
regulation of cell proliferation, differentiation and death. Among these modifications …

INF2 is a formin protein that accelerates actin polymerization. A common mechanism for
formin regulation is autoinhibition, through interaction between the N-terminal diaphanous …