To facilitate a rapid response to environmental change, cells use scaffolding—or adaptor—
proteins to recruit key components of their signal-transduction machinery to specific …

Paxillin is a focal adhesion-associated, phosphotyrosine-containing protein that may play a
role in several signaling pathways. Paxillin contains a number of motifs that mediate protein …

The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) have a highly
homologous structure, but different biological effects. Insulin and IGF-I half-receptors can …

The Met receptor tyrosine kinase is the prototypic member of a small subfamily of growth
factor receptors that when activated induce mitogenic, motogenic, and morphogenic cellular …

Crk family adaptors are widely expressed and mediate the timely formation of signal
transduction protein complexes upon a variety of extracellular stimuli, including various …

The focal adhesion kinase, FAK, is an important component of an integrin-dependent
signaling pathway, which functions to transmit signals from the extracellular matrix into the …

Abstract Heterozygous deletions of 17p13. 3 result in the human neuronal migration
disorders isolated lissencephaly sequence (ILS) and the more severe Miller–Dieker …

Abstract The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of
essential signal transduction pathways in humans and other organisms that act as major …

Gab1 is a substrate of the receptor tyrosine kinase c-Met and involved in c-Met–specific
branching morphogenesis. It associates directly with c-Met via the c-Met–binding domain …

In PC12 cells, epidermal growth factor (EGF) transiently stimulates the mitogen-activated
protein (MAP) kinases, ERK1 and ERK2, and provokes cellular proliferation. In contrast …