Steatotic liver disease

M Israelsen, S Francque, EA Tsochatzis, A Krag - The Lancet, 2024 - thelancet.com
Steatotic liver disease is the overarching term for conditions characterised by abnormal lipid
accumulation in the liver (liver or hepatic steatosis). Steatotic liver disease encompasses …

[HTML][HTML] Noninvasive assessment of hepatic decompensation

M Thiele, S Johansen, M Israelsen, J Trebicka… - Hepatology, 2023 - journals.lww.com
Noninvasive tests (NITs) are used in all aspects of liver disease management. Their most
prominent break-through since the millennium has been in advancing early detection of liver …

Rifaximin-α for liver fibrosis in patients with alcohol-related liver disease (GALA-RIF): a randomised, double-blind, placebo-controlled, phase 2 trial

M Israelsen, BS Madsen, N Torp… - The Lancet …, 2023 - thelancet.com
Background Alcohol is the leading cause of liver-related mortality worldwide. The gut–liver
axis is considered a key driver in alcohol-related liver disease. Rifaximin-α improves gut …

MetALD: new opportunities to understand the role of alcohol in steatotic liver disease

M Israelsen, N Torp, S Johansen, M Thiele… - The Lancet …, 2023 - thelancet.com
For many years non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease
(ALD) have been considered as two biologically and clinically distinct conditions. According …

Distinct structural and dynamic components of portal hypertension in different animal models and human liver disease etiologies

P Königshofer, BS Hofer, K Brusilovskaya… - Hepatology, 2022 - journals.lww.com
Distinct structural and dynamic components of portal hyperte... : Hepatology Distinct structural
and dynamic components of portal hypertension in different animal models and human liver …

Systemic inflammation is linked to liver fibrogenesis in patients with advanced chronic liver disease

B Simbrunner, IF Villesen, P Königshofer… - Liver …, 2022 - Wiley Online Library
Abstract Background & Aims Experimental evidence indicates that systemic inflammation
(SI) promotes liver fibrogenesis. This study investigated the potential link between SI and …

Binge drinking induces an acute burst of markers of hepatic fibrogenesis (PRO‐C3)

N Torp, M Israelsen, MJ Nielsen, CP Åstrand… - Liver …, 2022 - Wiley Online Library
Abstract Background & Aims Binge drinking is associated with an increased risk of liver
disease. Morbidity and mortality of alcohol‐related liver disease (ALD) is associated with …

Non-invasive tests for alcohol-associated liver disease

M Israelsen, W Rungratanawanich, M Thiele… - Hepatology, 2024 - journals.lww.com
Alcohol consumption is a global phenomenon and a major contributor to alcohol-associated
liver disease (ALD). Detecting individuals at risk of ALD has been challenging, with only a …

[HTML][HTML] Stage-dependent expression of fibrogenic markers in alcohol-related liver disease

MD Sørensen, M Thiele, A Krag, SJ Daniels… - … -Research and Practice, 2022 - Elsevier
Alcohol-related liver disease (ALD) is the primary cause of liver-related mortality and
morbidity. Liver fibrosis remains the best validated surrogate marker for patient prognosis …

[HTML][HTML] Transforming steatotic liver disease management: The emerging role of GLP-1 receptor agonists

EL Jensen, M Israelsen, A Krag - Hepatology Communications, 2024 - journals.lww.com
Chronic liver disease is a major cause of mortality, with approximately 2 million deaths
worldwide each year, and it poses a significant economic burden. The most common cause …