Research into the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has
led to remarkable advances in our understanding of the disease. Mutations now allow us to …

Myelodysplasia is a diagnostic feature of myelodysplastic syndromes (MDSs) but is also
found in other myeloid neoplasms. Its molecular basis has been recently elucidated by …

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical
characteristics has been complicated by histological and aetiological heterogeneity. Here …

To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we
investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 …

Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral
heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome …

Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2
play an essential role in gene regulation, cellular differentiation, and development. However …

Despite gains in survival, outcomes for patients with metastatic or recurrent
rhabdomyosarcoma remain dismal. In a collaboration between the National Cancer Institute …

Medulloblastomas are the most common malignant brain tumours in children. Identifying
and understanding the genetic events that drive these tumours is critical for the development …

The addressable pocket of a protein is often not functionally relevant in disease. This is true
for the multidomain, bromodomain-containing transcriptional regulator TRIM24. TRIM24 has …

The completion of a reference genome sequence for humans took more than 200 scientists
more than a decade in a project that cost almost $3 billion to complete (International Human …