Quorum sensing gene regulation by LuxR/HapR master regulators in vibrios

AS Ball, RR Chaparian, JC van Kessel - Journal of bacteriology, 2017 - Am Soc Microbiol
The coordination of group behaviors in bacteria is accomplished via the cell-cell signaling
process called quorum sensing. Vibrios have historically been models for studying bacterial …

Modeling tubercular ESX-1 secretion using Mycobacterium marinum

AE Chirakos, A Balaram, W Conrad… - … and Molecular Biology …, 2020 - Am Soc Microbiol
Pathogenic mycobacteria cause chronic and acute diseases ranging from human
tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute …

The breadth and molecular basis of Hcp-driven type VI secretion system effector delivery

SA Howard, RCD Furniss, D Bonini, H Amin… - MBio, 2021 - Am Soc Microbiol
The type VI secretion system (T6SS) is a bacterial nanoscale weapon that delivers toxins
into prey ranging from bacteria and fungi to animal hosts. The cytosolic contractile sheath of …

Mycobacterium tuberculosis toxin CpnT is an ESX-5 substrate and requires three type VII secretion systems for intracellular secretion

B Izquierdo Lafuente, R Ummels, C Kuijl, W Bitter… - MBio, 2021 - Am Soc Microbiol
CpnT, a NAD+ glycohydrolase, is the only known toxin that is secreted by Mycobacterium
tuberculosis. CpnT is composed of two domains; the C-terminal domain is the toxin, whereas …

A cyanobacterial component required for pilus biogenesis affects the exoproteome

Y Yegorov, E Sendersky, S Zilberman, E Nagar… - MBio, 2021 - Am Soc Microbiol
Protein secretion as well as the assembly of bacterial motility appendages are central
processes that substantially contribute to fitness and survival. This study highlights …

Structure of an inner membrane protein required for PhoPQ-regulated increases in outer membrane cardiolipin

J Fan, EM Petersen, TR Hinds, N Zheng, SI Miller - MBio, 2020 - Am Soc Microbiol
The Salmonella enterica subsp. enterica serovar Typhimurium PhoPQ two-component
system is activated within the intracellular phagosome environment, where it promotes …

Conserved ESX-1 substrates EspE and EspF are virulence factors that regulate gene expression

AE Chirakos, KR Nicholson, A Huffman… - Infection and …, 2020 - Am Soc Microbiol
Mycobacterium tuberculosis, the cause of human tuberculosis, and Mycobacterium
marinum, a nontubercular pathogen with a broad host range, require the ESX-1 secretion …

LuxT is a global regulator of low-cell-density behaviors, including type III secretion, siderophore production, and aerolysin production, in Vibrio harveyi

MJ Eickhoff, C Fei, JP Cong, BL Bassler - Mbio, 2022 - Am Soc Microbiol
Quorum sensing (QS) is a chemical communication process in which bacteria produce,
release, and detect extracellular signaling molecules called autoinducers. Via combined …

Flagellar genes are associated with the colonization persistence phenotype of the Drosophila melanogaster microbiota

SJ Morgan, JM Chaston - Microbiology Spectrum, 2023 - Am Soc Microbiol
In this work, we use Drosophila melanogaster as a model to identify bacterial genes
necessary for bacteria to colonize their hosts independent of the bulk flow of diet. Early work …

Versatile Oxidase and Dehydrogenase Activities of Bacterial Pyranose 2-Oxidase Facilitate Redox Cycling with Manganese Peroxidase In Vitro

PL Herzog, L Sützl, B Eisenhut, D Maresch… - Applied and …, 2019 - Am Soc Microbiol
ABSTRACT Pyranose 2-oxidase (POx) has long been accredited a physiological role in
lignin degradation, but evidence to provide insights into the biochemical mechanisms and …