Connecting the dots between hypercholesterolemia and Alzheimer's disease: a potential mechanism based on 27-hydroxycholesterol
M Wu, Y Zhai, X Liang, W Chen, R Lin, L Ma… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD), the most common cause of dementia, is a complex and
multifactorial disease involving genetic and environmental factors, with …
multifactorial disease involving genetic and environmental factors, with …
Unraveling the Impact of 27-Hydroxycholesterol in autoimmune diseases: exploring promising therapeutic approaches
Abstract The role of 27-hydroxycholesterol (27-OHC) in autoimmune diseases has become
a subject of intense research in recent years. This oxysterol, derived from cholesterol, has …
a subject of intense research in recent years. This oxysterol, derived from cholesterol, has …
[HTML][HTML] AT1 receptor autoantibodies mediate effects of metabolic syndrome on dopaminergic vulnerability
MA Pedrosa, CM Labandeira, R Valenzuela… - Brain, Behavior, and …, 2023 - Elsevier
The metabolic syndrome has been associated to chronic peripheral inflammation and
related with neuroinflammation and neurodegeneration, including Parkinson's disease …
related with neuroinflammation and neurodegeneration, including Parkinson's disease …
27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial
A Sandebring-Matton, J Goikolea, I Björkhem… - Alzheimer's Research & …, 2021 - Springer
Abstract Background 27-Hydroxycholesterol (27-OH), the main circulating oxysterol in
humans and the potential missing link between peripheral hypercholesterolemia and …
humans and the potential missing link between peripheral hypercholesterolemia and …
Resveratrol Alleviates 27‐Hydroxycholesterol‐Induced Senescence in Nerve Cells and Affects Zebrafish Locomotor Behavior via Activation of SIRT1‐Mediated STAT3 …
J Liu, K Jiao, Q Zhou, J Yang, K Yang… - Oxidative Medicine …, 2021 - Wiley Online Library
The oxysterol 27‐hydroxycholesterol (27HC) is the first identified endogenous selective
estrogen receptor modulator (SERM), which like endogenous estrogen 17β‐estradiol (E2) …
estrogen receptor modulator (SERM), which like endogenous estrogen 17β‐estradiol (E2) …
27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior
Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among
these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the …
these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the …
The Interaction Effect of 27‐Hydroxycholesterol Metabolism Disorder and CYP27A1 Single Nucleotide Polymorphisms in Mild Cognitive Impairment: Evidence from a …
L Wang, H Yu, L Hao, M Ju, W Feng… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope The aim of the study is to investigate the relationship between 27‐hydroxycholesterol
(27‐OHC), 27‐hydroxylase (CYP27A1) polymorphisms, and Alzheimer's disease (AD) …
(27‐OHC), 27‐hydroxylase (CYP27A1) polymorphisms, and Alzheimer's disease (AD) …
Borneol and lactoferrin dual-modified crocetin-loaded nanoliposomes enhance neuroprotection in HT22 cells and brain targeting in mice
Z Tong, X Jie, Z Chen, M Deng, X Li, Z Zhang… - European Journal of …, 2024 - Elsevier
Crocetin (CCT), a natural bioactive compound extracted and purified from the traditional
Chinese medicinal herb saffron, has been shown to play a role in neurodegenerative …
Chinese medicinal herb saffron, has been shown to play a role in neurodegenerative …
Sex Differences in the Association Between LDL/HDL with Cognitive Decline in Older Adults: National Health and Nutrition Examination Survey
J Wen, X Hao, Y Jia, B Wang, J Pang… - Journal of Alzheimer's …, 2024 - content.iospress.com
Background: Lipids have a significant impact on the development and functioning of the
nervous system, but the sex differences between the association of LDL/HDL, which reflects …
nervous system, but the sex differences between the association of LDL/HDL, which reflects …
AT1 receptor autoantibodies mediate effects of metabolic syndrome on dopaminergic vulnerability
MÁ Pedrosa Sánchez, CM Labandeira Guerra… - 2023 - minerva.usc.es
The metabolic syndrome has been associated to chronic peripheral inflammation and
related with neuroinflammation and neurodegeneration, including Parkinson's disease …
related with neuroinflammation and neurodegeneration, including Parkinson's disease …