Neuromodulation in epilepsy: state-of-the-art approved therapies

P Ryvlin, S Rheims, LJ Hirsch, A Sokolov… - The Lancet …, 2021 - thelancet.com
Three neuromodulation therapies have been appropriately tested and approved in refractory
focal epilepsies: vagus nerve stimulation (VNS), deep brain stimulation of the anterior …

Deep brain stimulation: current challenges and future directions

AM Lozano, N Lipsman, H Bergman, P Brown… - Nature Reviews …, 2019 - nature.com
The clinical use of deep brain stimulation (DBS) is among the most important advances in
the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly …

The pharmacoresistant epilepsy: an overview on existant and new emerging therapies

A Fattorusso, S Matricardi, E Mencaroni… - Frontiers in …, 2021 - frontiersin.org
Epilepsy is one of the most common neurological chronic disorders, with an estimated
prevalence of 0. 5–1%. Currently, treatment options for epilepsy are predominantly based on …

The SANTÉ study at 10 years of follow‐up: effectiveness, safety, and sudden unexpected death in epilepsy

V Salanova, MR Sperling, RE Gross, CP Irwin… - …, 2021 - Wiley Online Library
Objective We evaluated the efficacy and safety of deep brain anterior thalamus stimulation
after 7 and 10 years, and report the incidence of sudden unexpected death in epilepsy …

Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy

DR Nair, KD Laxer, PB Weber, AM Murro, YD Park… - Neurology, 2020 - AAN Enterprises
Objective To prospectively evaluate safety and efficacy of brain-responsive neurostimulation
in adults with medically intractable focal onset seizures (FOS) over 9 years. Methods Adults …

A long short-term memory deep learning network for the prediction of epileptic seizures using EEG signals

ΚΜ Tsiouris, VC Pezoulas, M Zervakis… - Computers in biology …, 2018 - Elsevier
The electroencephalogram (EEG) is the most prominent means to study epilepsy and
capture changes in electrical brain activity that could declare an imminent seizure. In this …

Seizure prediction—ready for a new era

L Kuhlmann, K Lehnertz, MP Richardson… - Nature Reviews …, 2018 - nature.com
Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …

Current and future directions of deep brain stimulation for neurological and psychiatric disorders: JNSPG 75th Anniversary Invited Review Article

DJ Lee, CS Lozano, RF Dallapiazza… - Journal of neurosurgery, 2019 - thejns.org
Deep brain stimulation (DBS) has evolved considerably over the past 4 decades. Although it
has primarily been used to treat movement disorders such as Parkinson's disease, essential …

Deep brain stimulation targets in epilepsy: systematic review and meta‐analysis of anterior and centromedian thalamic nuclei and hippocampus

A Vetkas, A Fomenko, J Germann, C Sarica… - …, 2022 - Wiley Online Library
Deep brain stimulation (DBS) is a neuromodulatory treatment used in patients with drug‐
resistant epilepsy (DRE). The primary goal of this systematic review and meta‐analysis is to …