Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …
implicated to an array of bioactivities investigated by a series of preclinical and clinical …
Chalcones: Synthetic chemistry follows where nature leads
Chalcones belong to the flavonoid class of phenolic compounds. They form one of the
largest groups of bioactive natural products. The potential anticancer, anti-inflammatory …
largest groups of bioactive natural products. The potential anticancer, anti-inflammatory …
Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis
MH Nematollahi, M Mehrabani, Y Hozhabri… - Heliyon, 2023 - cell.com
Chalcones and their derivatives have been widely studied due to their versatile
pharmacological and biological activities, such as anti-inflammatory, antibacterial, antiviral …
pharmacological and biological activities, such as anti-inflammatory, antibacterial, antiviral …
Design, synthesis, and antibacterial and antifungal activities of novel trifluoromethyl and trifluoromethoxy substituted chalcone derivatives
Despite the availability of many drugs to treat infectious diseases, the problems like narrow
antimicrobial spectrum, drug resistance, hypersensitivities and systemic toxicities are …
antimicrobial spectrum, drug resistance, hypersensitivities and systemic toxicities are …
Synthesis and characterization of new thiosemicarbazones, as potent urease inhibitors: In vitro and in silico studies
A new series of N-substituted thiosemicarbazones (3a-u) bearing 2-naphthyl and
dihydrobenzofuranyl scaffolds were synthesized in good to excellent yields (78–95%). The …
dihydrobenzofuranyl scaffolds were synthesized in good to excellent yields (78–95%). The …
Supramolecular assembly involving weak hydrogen bonds, anti-parallel π··· π stacking and O··· C tetrel bonding interactions and LOX studies in a 1H-pyrazol-1-yl) …
In this manuscript, we synthesized a novel ethyl 2-(5-(4-methoxyphenyl)-3-phenyl-4, 5-
dihydro-1H-pyrazol-1-yl) thiazole-4-carboxylate (5) from the reaction acetophenone with 3 …
dihydro-1H-pyrazol-1-yl) thiazole-4-carboxylate (5) from the reaction acetophenone with 3 …
Direct antibacterial and antibiotic resistance modulatory activity of chalcones synthesized from the natural product 2-hydroxy-3, 4, 6-trimethoxyacetophenone
TS Freitas, JC Xavier, RLS Pereira… - FEMS microbiology …, 2020 - academic.oup.com
Antibiotic for clinical use lose its effectiveness over time due to bacterial resistance. In this
work, four chalcones with modifications in their ligands were synthesized from the natural …
work, four chalcones with modifications in their ligands were synthesized from the natural …
Furan-based Chalcone Annihilates the Multi-Drug-Resistant Pseudomonas aeruginosa and Protects Zebra Fish Against its Infection
The emergence of carbapenem-resistant Pseudomonas aeruginosa, a multi-drug-resistant
bacteria, is becoming a serious public health concern. This bacterium infects …
bacteria, is becoming a serious public health concern. This bacterium infects …
Photophysical study and biological applications of synthetic chalcone-based fluorescent dyes
S Wangngae, K Chansaenpak, J Nootem, U Ngivprom… - Molecules, 2021 - mdpi.com
A chalcone series (3a–f) with electron push–pull effect was synthesized via a one-pot
Claisen–Schmidt reaction with a simple purification step. The compounds exhibited strong …
Claisen–Schmidt reaction with a simple purification step. The compounds exhibited strong …
Biological effects and mechanisms of dietary chalcones: latest research progress, future research strategies, and challenges
YL Zhang, SJ Sun, L Zeng - Food & Function, 2024 - pubs.rsc.org
Dietary plants are an indispensable part of the human diet, and the various natural active
compounds they contain, especially polyphenols, polysaccharides, and amino acids, have …
compounds they contain, especially polyphenols, polysaccharides, and amino acids, have …