Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors

C Wang, DM Holtzman - Neuropsychopharmacology, 2020 - nature.com
As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

A systemic view of Alzheimer disease—insights from amyloid-β metabolism beyond the brain

J Wang, BJ Gu, CL Masters, YJ Wang - Nature reviews neurology, 2017 - nature.com
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …

Obstructive sleep apnea, cognition and Alzheimer's disease: a systematic review integrating three decades of multidisciplinary research

OM Bubu, AG Andrade, OQ Umasabor-Bubu… - Sleep medicine …, 2020 - Elsevier
Increasing evidence links cognitive-decline and Alzheimer's disease (AD) to various sleep
disorders, including obstructive sleep apnea (OSA). With increasing age, there are …

Trends in CPAP adherence over twenty years of data collection: a flattened curve

BW Rotenberg, D Murariu… - Journal of Otolaryngology …, 2016 - journals.sagepub.com
Background Obstructive sleep apnea (OSA) is a common disorder, and continuous airway
positive pressure (CPAP) is considered to be the gold standard of therapy. CPAP however is …

[HTML][HTML] Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

KL Lanctôt, J Amatniek, S Ancoli-Israel… - Alzheimer's & Dementia …, 2017 - Elsevier
Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing
substantial distress for both people with dementia and their caregivers, and contributing to …

Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease

BP Lucey, A McCullough, EC Landsness… - Science translational …, 2019 - science.org
In Alzheimer's disease (AD), deposition of insoluble amyloid-β (Aβ) is followed by
intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic …

Connections between sleep and cognition in older adults

K Yaffe, CM Falvey, T Hoang - The Lancet Neurology, 2014 - thelancet.com
Sleep disturbances and cognitive impairment are common in older adults. Mounting
evidence points to a potential connection between sleep and cognitive function. Findings …

Aging and Alzheimer's disease: comparison and associations from molecular to system level

X Xia, Q Jiang, J McDermott, JDJ Han - Aging cell, 2018 - Wiley Online Library
Alzheimer's disease is the most prevalent cause of dementia, which is defined by the
combined presence of amyloid and tau, but researchers are gradually moving away from the …

[HTML][HTML] Promoting successful cognitive aging: a ten-year update

TJ Krivanek, SA Gale, BM McFeeley… - Journal of …, 2021 - content.iospress.com
A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …