Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

The importance of stereochemistry in drug action is gaining greater attention in medical
practice, and a basic knowledge of the subject will be necessary for clinicians to make …

Major depressive disorder is the main cause of disability worldwide with imperfect treatment
options. However, novel therapeutic approaches are currently discussed, from augmentation …

PURPOSE Depression is common in primary care. There are no systematic reviews of
depression treatment comparing antidepressants with placebo; hence, we do not know …

From clinical studies it is known that recurrent depressive episodes associate with a reduced
hippocampal volume. Conversely, preclinical studies have shown that chronic …

Background: Escitalopram is the single isomer responsible for the serotonin reuptake
inhibition produced by the racemic antidepressant citalopram. The present randomized …

Escitalopram is the (S)-enantiomer of the racemic selective serotonin reuptake inhibitor
antidepressant citalopram. Clinical studies have shown that escitalopram is effective and …

Rationale Citalopram is a racemate consisting of a 1: 1 mixture of the R (−)-and S (+)-
enantiomers. Non-clinical studies show that the serotonin reuptake inhibitory activity of …

Objective The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram,
was studied and compared with citalopram and the R-(−)-enantiomer, R-citalopram …

Escitalopram was compared to placebo in moderately to severely depressed patients in
primary care with citalopram as the active reference. Patients were randomized to receive …