Fibroblasts regulate the structure and function of healthy tissues, participate transiently in
tissue repair after acute inflammation, and assume an aberrant stimulatory role during …

Angiogenesis is a vital process for the growth and dissemination of solid cancers. Numerous
molecular pathways are known to drive angiogenic switch in cancer cells promoting the …

The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …

Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the
function of melanoma-derived exosomes in the formation of primary tumors and metastases …

The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of
proliferation, differentiation and survival. The induction of these pathways depends on …

c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth
factor, activates a wide range of different cellular signaling pathways, including those …

Maintenance of both normal epithelial tissues and their malignant counterparts is supported
by the host tissue stroma. The tumor stroma mainly consists of the basement membrane …

Kidney cancer is not a single disease but comprises a number of different types of cancer
that occur in the kidney, each caused by a different gene with a different histology and …

Head and neck cancer (HNC) broadly includes carcinomas arising from the mucosal
epithelia of the head and neck region as well as various cell types of salivary glands and the …

In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …