Genetics and epigenetics of autism spectrum disorder—current evidence in the field

B Wiśniowiecka-Kowalnik, BA Nowakowska - Journal of applied genetics, 2019 - Springer
Autism spectrum disorders (ASD) is a heterogenous group of neurodevelopmental disorders
characterized by problems in social interaction and communication as well as the presence …

Interplay between MicroRNAs and oxidative stress in neurodegenerative diseases

J Konovalova, D Gerasymchuk, I Parkkinen… - International journal of …, 2019 - mdpi.com
MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Growth and folding of the mammalian cerebral cortex: from molecules to malformations

T Sun, RF Hevner - Nature Reviews Neuroscience, 2014 - nature.com
The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

MicroRNAs in neural development: from master regulators to fine-tuners

M Rajman, G Schratt - Development, 2017 - journals.biologists.com
The proper formation and function of neuronal networks is required for cognition and
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …

Determining the role of microRNAs in psychiatric disorders

O Issler, A Chen - Nature Reviews Neuroscience, 2015 - nature.com
Recent studies have revealed that patients with psychiatric disorders have altered
microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal …

Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

Y Shimono, M Zabala, RW Cho, N Lobo, P Dalerba… - cell, 2009 - cell.com
Human breast tumors contain a breast cancer stem cell (BCSC) population with properties
reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed …

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

IA Qureshi, MF Mehler - Nature Reviews Neuroscience, 2012 - nature.com
Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a
rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture …

Early-life experience, epigenetics, and the developing brain

M Kundakovic, FA Champagne - Neuropsychopharmacology, 2015 - nature.com
Abstract Development is a dynamic process that involves interplay between genes and the
environment. In mammals, the quality of the postnatal environment is shaped by parent …

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

H Kaneko, S Dridi, V Tarallo, BD Gelfand, BJ Fowler… - Nature, 2011 - nature.com
Geographic atrophy (GA), an untreatable advanced form of age-related macular
degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we …