Background Concerns regarding the safety of transfused blood have led to the development
of a range of interventions to minimise blood loss during major surgery. Anti‐fibrinolytic …

BACKGROUND: A minority of patients having cardiac procedures (15% to 20%) consume
more than 80% of the blood products transfused at operation. Blood must be viewed as a …

When bleeding is the consequence of a specific defect of hemostasis, the goal of treatment
is to correct the defect. A typical example is the replacement of factor VIII by transfusion in …

I the enhancement of blood clotting associated with stress was caused by the liberation of
adrenaline in plasma. 6, 7 In 1957, N 1977 DESMOPRESSIN (1-deamino-8-D-arginine …

Background Excessive bleeding may complicate cardiac surgery, and is associated with
increased morbidity and mortality. Pharmacological strategies to decrease perioperative …

Background—Since the 1980s, antifibrinolytic therapies have assisted surgical teams in
reducing the amount of blood loss. To date, however, serious questions remain regarding …

Concern about the side effects of allogeneic red blood cell transfusion has increased
interest in methods of minimizing perioperative transfusion. We performed meta-analyses of …

Background Aprotinin is a serine protease inhibitor used to limit perioperative bleeding and
reduce the need for donated blood transfusions during cardiac surgery. Randomized …

Background Public concerns regarding the safety of blood have prompted reconsideration of
the use of allogeneic blood (blood from an unrelated donor) transfusion and a range of …

Results: In most of the included studies, 0.3 g/kg desmo-pressin was used prophylactically
over a 15-to 30-min period. In comparison with placebo, desmopressin was associated with …